Tara Sigdel, Ph.D.
- Associate Professor of Surgery
- Division of Transplant Surgery
Contact Information
Education
B.Sc. (Biology and Chemistry) Tribhuvan University, Kathmandu, Nepal
M.Sc. (Chemistry) Tribhuvan University, Kathmandu, Nepal, Advisor: Prof. Vishwanath Pd. Agrawal, PhD
Ph.D. (Biochemistry), Miami University, Oxford, OH, Advisor: Prof. Michael Crowder, PhD
Biography
Tara Sigdel, Ph.D. obtained his Ph.D. in biochemistry from Miami University (OH) followed by postdoctoral training in biomarker discovery, immunology, and organ transplantation at Stanford University under Professor Minnie Sarwal. Dr Sigdel joined the UCSF Department of Surgery in 2014 where he uses proteomics, immune response profiling, and gene expression analysis to discover sensitive and effective biomarkers that help in developing clinical tools for early diagnosis and improved patient monitoring. In collaboration with researchers at UCSF and other institutes, Dr. Sigdel is actively involved in identification of non-invasive biomarkers genes, peptides, proteins, and antibodies that monitor disease status after organ transplantation.
Awards & Honors
Research Overview
Dr. Sigdel's research is driven by two major factors. First, there is an unprecedented pressure to deliver new and improved diagnostic and treatment options to patients. Second, due to improved understanding of biological intricacies with ever improving molecular assays have placed us in a much better position to look for disease specific biomarkers that once validated can be used in the clinics in order to provide timely and accurate assessment of health status of patients.
Publications
MOST RECENT PUBLICATIONS FROM A TOTAL OF 95
- Boada P, Fatou B, Belperron AA, Sigdel TK, Smolen KK, Wurie Z, Levy O, Ronca SE, Murray KO, Liberto JM, Rashmi P, Kerwin M, Montgomery RR, Bockenstedt LK, Steen H, Sarwal MM. Longitudinal serum proteomics analyses identify unique and overlapping host response pathways in Lyme disease and West Nile virus infection. Front Immunol. 2022; 13:1012824. View in PubMed
- Sigdel TK, Fields PA, Liberto J, Damm I, Kerwin M, Hood J, Towfighi P, Sirota M, Robins HS, Sarwal MM. Perturbations of the T-cell immune repertoire in kidney transplant rejection. Front Immunol. 2022; 13:1012042. View in PubMed
- Hansen J, Sealfon R, Menon R, Eadon MT, Lake BB, Steck B, Anjani K, Parikh S, Sigdel TK, Zhang G, Velickovic D, Barwinska D, Alexandrov T, Dobi D, Rashmi P, Otto EA, Rivera M, Rose MP, Anderton CR, Shapiro JP, Pamreddy A, Winfree S, Xiong Y, He Y, de Boer IH, Hodgin JB, Barisoni L, Naik AS, Sharma K, Sarwal MM, Zhang K, Himmelfarb J, Rovin B, El-Achkar TM, Laszik Z, He JC, Dagher PC, Valerius MT, Jain S, Satlin LM, Troyanskaya OG, Kretzler M, Iyengar R, Azeloglu EU, Kidney Precision Medicine Project. A reference tissue atlas for the human kidney. Sci Adv. 2022 06 10; 8(23):eabn4965. View in PubMed
- Ishiyama K, Arakawa-Hoyt J, Aguilar OA, Damm I, Towfighi P, Sigdel T, Tamaki S, Babdor J, Spitzer MH, Reed EF, Sarwal MM, Lanier LL, CMV Systems Immunobiology Group. Mass cytometry reveals single-cell kinetics of cytotoxic lymphocyte evolution in CMV-infected renal transplant patients. Proc Natl Acad Sci U S A. 2022 02 22; 119(8). View in PubMed
- Sur S, Nguyen M, Boada P, Sigdel TK, Sollinger H, Sarwal MM. FcER1: A Novel Molecule Implicated in the Progression of Human Diabetic Kidney Disease. Front Immunol. 2021; 12:769972. View in PubMed
- View All Publications
In the News
- Sarwal Lab - August 03, 2016Natera, a genetic testing and diagnostics company with proprietary bioinformatics and molecular technology, has announced that it has formed a collaboration with the Sarwal Lab at University of California San Francisco to study DNA markers of kidney transplant rejection.The Sarwal Lab has been focused on using precision medicine techniques to better diagnose and predict acute rejection (AR) in kidney transplants, a finding that eventually could replace the need for biopsies and lead to earlier [...]
- Sarwal Lab - - February 17, 2016Joshua Y. Yang, B.S., Michael C. Nasr, B.S., and Tyler Schmeckpeper B.S., Master of Translational Medicine (MTM), graduate student researchers in the Sarwal Lab, were recently invited to attend the 9th annual Clinton Global Initiative University (CGI U) 2016 at UC Berkeley on April 1-3, 2016, and selected as presenters to disucss their work. The MTM program, a cross-campus collaboration between two University of California campuses—San Francisco and Berkeley, and launched with the help of [...]
- Sarwal Lab - - March 25, 2015International Innovation, an online forum for the communication and dissemination of cutting-edge research, recently reported on the pioneering efforts of the Sarwal Lab to develop novel translational approaches for improving the management of kidney transplant patients and treating renal disease. The article reports on the lab's breakthrough assays, the kidney solid organ rejection test (kSORT) and the kidney spontaneous operational tolerance test (kSPOT), and their potential [...]
- Sarwal Lab - December 01, 2014UCSF News reports on research led by Minnie Sarwal, MD, PhD, Director of the Sarwal Lab, in developing a test for diagnosing and predicting acute rejection (AR) in kidney transplants, a finding that eventually could replace the need for biopsies and lead to earlier detection of AR and treatment. 'We have found a set of genes in blood that pick up inflammation and acute rejection in different solid organ transplants and thus can replace the need for an invasive biopsy in the future,' said [...]
- Sarwal Lab - October 06, 2014UCSF News recently reported on research of the Sarwal Lab demonstrating pre-transplant antibody levels were associated with recurrence of FSGS. Researchers at UC San Francisco and Rush University Medical Center, Chicago, may have found a predictor for a disorder affecting kidney transplant recipients that can accelerate organ failure, a discovery that eventually could allow for customized therapies and improved patient selection for transplant. The study of focal segmental glomerulosclerosis [...]
